Publications

    Since 2004
  1. Agrawal A, Rangarajan N, Weisshaar JC (2019) Resistance of early stationary phase E. coli to membrane permeabilization by the antimicrobial peptide Cecropin A.Biochimica et Biophysica acta doi.org/10.1016/j.bbamem.2019.05.012
  2. Mustafi M, Weisshaar JC (2019) Near Saturation of Ribosomal L7/L12 Binding Sites with Ternary Complexes in Slowly Growing  E. coli. J Mol Biol. doi.org/10.1016/j.jmb.2019.04.037
  3. Zhu Y, Mohapatra S, Weisshaar JC (2019) Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy. PNAS. doi.org/10.1073/pnas.1814924116
  4. Mohapatra S, Weisshaar JC (2018) Modified Pearson correlation coefficient for two-color imaging in spherocylindrical cells. BMC Bioinformatics. doi:10.1186/s12859-018-2444-3
  5. Mohapatra S, Weisshaar JC (2018) Functional mapping of the E. coli translational machinery using single‐molecule tracking. Mol. Microbiol. doi:10.1111/mmi.14103
  6. Yang Z, Weisshaar JC (2018) HaloTag Assay Suggests Common Mechanism of E. coli Membrane Permeabilization Induced by Cationic Peptides. ACS Chemical Biology doi:10.1021/acschembio.8b00336
  7. Agrawal A, Weisshaar JC (2018) Effects of alterations of the E. coli lipopolysaccharide layer on membrane permeabilization events induced by Cecropin A. Biochimica et Biophysica acta https://doi.org/10.1016/j.bbamem.2018.04.009
  8. Yang Z, Choi H, Weisshaar JC (2018) Melittin-Induced Permeabilization, Re-sealing, and Re-permeabilization of E. coli Membranes. Biophysical Journal doi:10.1016/j.bpj.2017.10.046
  9. Mustafi M, Weisshaar JC (2018) Simultaneous Binding of Multiple EF-Tu Copies to Translating Ribosomes in Live Escherichia coli. mBio https://doi.org/10.1128/mBio.02143-17
  10. Choi H, Yang Z, Weisshaar JC. (2017) Oxidative stress induced in E. coli by the human antimicrobial peptide LL-37. Plos Pathogens doi.org/10.1371/journal.ppat.1006481
  11. Mohapatra S, Choi H, Ge X, Sanyal S, Weisshaar JC. (2017) Spatial Distribution and Ribosome-binding Dynamics of EF-P in Live E. coli. mBio doi: 10.1128/mBio.00300-17
  12. Barns KJ, Weisshaar JC. (2016) Single-cell, time-resolved study of the effects of the antimicrobial peptide alamethicin on Bacillus subtilis. Biochimica et Biophysica acta.  doi:10.1016/j.bbamem.2016.01.003
  13. Choi H, Chakraborty S, Liu R, Gellman SH, Weisshaar JC. (2015) Single-Cell, Time-Resolved Antimicrobial Effects on a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli. ACS Chemical Biology. 10.1021/acschembio.5b00547
  14. Choi H, Rangarajan N, Weisshaar JC. (2015) Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time. Trends in Microbiology. doi:10.1016/j.tim.2015.11.004
  15. Li W, Bouveret E, Zhang Y, K Liu, Wang J, Weisshaar JC. (2015) Effects of Amino Acid Starvation on RelA Diffusive Behavior in Live Escherichia coli. Molecular Microbiology. 10.1111/mmi.13252
  16. Bakshi S, Choi H, Weisshaar JC. (2015) The Spatial Biology of Transcription and Translation in Rapidly Growing Escherichia coli. Frontiers in Microbiology. 10.3389/fmicb.2015.00636
  17. Choi H, Yang Z, Weisshaar JC. (2015) Single-Cell, Real-time Detection of Oxidative Stress Induced in E. coli by the Antimicrobial Peptide CM15. Proceedings in National Academy of Sciences. 10.1073/pnas.1417703112
  18. Bakshi S, Choi H, Mondal J, Weisshaar JC. (2014) Time-dependent effects of transcription-and translation-halting drugs on the spatial distributions of the Escherichia coli chromosome and ribosomes. Molecular Microbiology.94 (4).871-887. 10.1111/mmi.12805 
  19. Bakshi S, Choi H, Rangarajan N, Barns KJ, Weisshaar JC. (2014) Non-perturbative Imaging of Nuceloid Morphology in Live Bacterial Cells during Antimicrobial Peptide Attack. Applied and Environmental Microbiology. 00989-14. 10.1128/AEM.00989-14
  20. Choi H, Chakraborty S, Liu R, Gellman SH, Weisshaar JC. (2014) Medium Effects on Minimum Inhibitory Concentrations of Nylon-3 Polymers against E. coli. Plos One. 9 (8). e104500. 10.1371/journal.pone.0104500
  21. Bakshi S, Li W, Dalrymple RM, Choi H, Weisshaar JC. (2013) Partitioning of RNA Polymerase Activity in Live E. coli from Analysis of Single-molecule Diffusive Trajectories. Biophysical Journal. 105 (12):2676–2686. 10.1016/j.bpj.2013.10.024
  22. Rangarajan N, Bakshi S, Weisshaar JC. (2013). Localized Permeabilization of E. coli Membranes by the Antimicrobial Peptide Cecropin A. Biochemistry 52 (38):6584-6594. 10.1021/bi400785j
  23. Barns KJ, Weisshaar, JC. (2013). Real-time Attack of LL-37 on Single Bacillus subtilis Cells. Biochim. Biophys. Acta. 1828:1511-1520.doi:10.1016/j.bbamem.2013.02.011
  24. Bakshi S, Siryaporn A, Goulian M ,Weisshaar JC. (2012). Superresolution imaging of ribosomes and RNA polymerase in Escherichia coli cells. Mol Microbiol. 85:21-36. doi:10.1111/j.1365-2958.2012.08081.x  
  25. Bakshi S, Bratton BP, Weisshaar JC. (2011). Subdiffraction-Limit Study of Kaede Diffusion and Spatial Distribution in Live Escherichia coli. Biophys J. 101:2535-2544 di:10.1016/j.bpj.2011.10.013
  26. Bratton BP, Mooney RA, Weisshaar JC. (2011). Spatial Distribution and Diffusive Motion of RNA Polymerase in Live Escherichia coli. J. Bacteriol. 193:5138-5146 doi:10.1128/JB.00198-11
  27. Mondal J, Bratton BP, Li Y, Yethiraj A, Weisshaar JC. (2011). Entropy-Based Mechanism of Ribosome-Nucleoid Segregation in E. coli cells  . Biophys J. 100:2605-2613 doi:10.1016/j.bpj.2011.04.030
  28. Smith EA, Weisshaar JC. (2011). Docking, Not Fusion, as the Rate-Limiting Step in a SNARE-Deriven Vesicle Fusion Assay. Biophys J. 100:2141-2150 doi:10.1016/j.bpj.2011.03.015
  29. Sochacki KA, Barns KJ, Bucki R, Weisshaar JC. (2011). Real-time Attack on Single Escherichia coli cells by human antimicrobial peptide LL-37. PNAS. 108: E77-81. doi:10.1073/pnas.1101130108
  30. Sochacki KA, Shkel IA, Record MT, Weisshaar JC. (2011). Protein Diffusion in the Periplasm of E. coli under Osmotic Stress. Biophys J. 100: 22-31. doi:10.1016/j.bpj.2010.11.044
  31. Wang T, Ingram CJ, Weisshaar JC. (2010). Model Lipid Membrane with Facile Diffusion of Lipids and Integral Membrane Proteins. Langmuir. 26: 11157-11164.doi:10.1021/la101046r
  32. Wang T, Smith EA, Chapman ER, Weisshaar JC. (2009). Lipid Mixing and Content Release in Single-Vesicle, SNARE-Driven Fusion Assay with 1-5 ms Resolution. Biophys. J. 96: 4122-4131. doi:10.1016/j.bpj.2009.02.050
  33. Konopka MC, Sochacki KA, Bratton BP, Shkel IA, Record MT Jr., Weisshaar JC. (2009). Cytoplasmic Protein Mobility in Osmotically Stressed Escherichia coli. J Bacteriol. 191: 231-237. doi:10.1128/JB.00536-08
  34. Liu T, Wang T, Chapman ER, Weisshaar JC. (2008). Productive Hemifusion Intermediates in Fast Vesicle Fusion Driven by Neuronal SNAREs. Biophys. J. 94: 1303-1314. doi:10.1529/biophysj.107.107896
  35. Yethiraj A, Weisshaar JC. (2007). Why Are Lipid Rafts Not Observed In Vivo? Biophys. J. 93: 3113-3119. doi:10.1529/biophysj.106.101931
  36. Konopka MC, Weisshaar JC, Record MT Jr. (2007). Methods of changing biopolymer volume fraction and cytoplasmic solute concentrations for in vivo biophysical studies. Methods Enzymol. 428: 487-504. doi:10.1016/S0076-6879(07)28027-9
  37. Konopka MC, Shkel IA, Cayley S, Record MT Jr., Weisshaar JC. (2006). Crowding and Confinement Effects on Protein Diffusion In Vivo. J Bacteriol. 188: 6115-6123. doi:10.1128/JB.01982-05
  38. Liu T, Tucker WC, Bhalla A, Chapman ER, Weisshaar JC. (2005). SNARE-Driven, 25-Millisecond Vesicle Fusion In Vitro. Biophys J. 89: 2458-2472. i:10.1529/biophysj.105.062539
  39. Konopka MC, Weisshaar JC. (2004). Heterogeneous Motion of Secretory Vesicles in the Actin Cortex of Live Cells: 3D Tracking to 5-nm Accuracy. J Phys Chem A. 108: 9814-9826. doi:10.1021/jp048162v